Fluconazole (Diflucan)

Fluconazole is an oral antifungal medication that is used to treat a wide range of fungal diseases. Although a drug called amphotericin B is currently the FDA-approved drug to treat endophthalmitis caused by fungal infection, there are concerns about its potential to cause renal damage and the need to administer it by intravenous infusion, as reported in the Archives of the Spanish Society of Ophthalmology. Those risks are raised when it is given in conjunction with certain other medications that the patient may be taking. In those instances, the physician may look to off-label anti-fungal drugs, such as generic Diflucan. This medication is often used as single dose therapy to treat some vaginal yeast infections.

Treatment of various fungal and yeast infections.

Endophthalmitis

Avoid taking this drug with antacids or other medications that decrease the stomach pH since this will reduce the fluconazole absorption.

Rifampin, cisapride, amiodarone, selected benzodiazepines, calcium channel blockers, citalopram, cyclosporine, diazepam, ergot derivatives, fluoxetine, glimepiride, glipizide, statin drugs (such as lovastatin, atorvastatin, etc.), methsuximide, mirtazapine, nateglinide, nefazodone, phenytoin, pioglitazone, propranolol, rosiglitazone, sertraline, sildenafil, tadalafil, tacrolimus, venlafaxine, warfarin.

May be taken with or without regard to food.

Unknown

FDA Pregnancy Risk Category C. Excreted in breast milk. Consult your doctor.

Where can I buy Diflucan without prescription?
Diflucan is a prescription drug that comes in 50mg, 100mg, 150mg, 200mg tablets. It is available on prescription only as tablets for oral use, but the online pharmacy, will sell Fluconazole without prescription. You may be able to order Diflucan from them online and save the local pharmacy markup.

The Spanish Society reported on the case of a patient with endophthalmitis due to the fungus Candida parapsilosis. The person was treated with amphotericin without success. Subsequently, the person was treated simultaneously with two off-label drugs - topical fluconazole and oral itraconazole - and they appeared to be effective in controlling the infection.

Additionally, oral fluconazole may be administered as reported by Indian researchers at the Joseph Eye hospital. They reported at a recent conference that in some cases this drug may be more effective than oral itraconazole because of its high water-soluble properties, which allow it to be absorbed into the body faster.

An earlier study reported in the Journal of Ocular Pharmacological Therapy had shown no retinal toxicity with Diflucan infusion and that it was effective in the treatment of experimental endophthalmitis due to the fungus candida.

This drug interferes with the production of fungal cell membrane and inhibits cell membrane formation.

Brand name
Diflucan

---

Generic name
Fluconazole

---

Chemical class
Triazole derivative

---

Therapeutic class
Antifungal

Tablets - Oral 50 mg, 100 mg, 150 mg, 200 mg.

ADULT
Cryptococcal meningitis: PO / IV 400 mg on 1st day, then 200 mg qd for 10-12 wk after CSF becomes culture negative; increase up to 400 mg/day based on response.

---

Esophageal candidiasis: PO / IV 200 mg on 1st day, then 100 mg qd for at least 3 wk and for 2 wk following resolution of symptoms; doses up to 400 mg/day may be used based on response.

---

Oropharyngeal candidiasis: PO/ IV 200 mg on 1st day, then 100 mg qd for at least 2 week.

---

Other candidiasis: PO / IV 50-200 mg/day, doses up to 400 mg/day may be used based on response.

---

Prevention of candidiasis in bone marrow transplant: PO / IV 400 mg qd, initiate several days before anticipated onset of neutropenia, continue 7 days after neutrophil count rises above 1000 cells/mm³.

---

Vaginal candidiasis: PO 150 mg as a single dose.

---

Renal function impairment: PO / IV reduce dose by 50% in patients with CrCl <50 ml/min.

---

CHILD
Equivalent doses for children are 3 mg/kg for adult dose of 100 mg; 6 mg/kg - 200 mg; 12 mg/kg - 400 mg; do not exceed 600 mg dose.